A corner layout works well with square rooms or when you are using part of another room. One of the important points to keep in mind with a corner layout is the position of any windows. If you happen to be facing a street, you may not wish for anyone and everyone to be able to see you.
Another consideration will be the placement of outlets and phone jacks. While this won't pose serious problems, you don't want to be using a lot of electrical extension cords. Try to arrange your workstation closest to the outlets so that your surge protectors can be plugged directly into them.